Sizing up human height variation. Nat Rev Genet 15 : 34— MOLF-Chr 19 chromosome substitution strain. A comprehensive analysis of common copy-number variations in the human genome. Nat Rev Cardiol 11 : — However, the additional time and expense of studying congenic strains typically reveals additional QTLs beyond those identified in the original screen.
The prediction is that if these sub-QTLs were studied in isolation, their effect sizes would be in line with those observed with other resources. This is my: About Gene Carrier Testing. Nat Genet 37 : — However, the decision to test does require consideration, in particular what the consequences will be to you should a positive result be given.
Mamm Genome 18 : 23— The results provide strong support for the hypothesis of generalist genes that has until now largely depended on quantitative genetic analyses of twin data. Various specialized resources have been developed to study complex traits in many model organisms.
Fractals are often found in nature including in coastlines, mountains, clouds, and plants Barnsley et al. Genome Res 10 : 42— This is my: About Gene Carrier Testing. The collaborative cross: a recombinant inbred mouse population for the systems genetic era.
A genetic marker near Cntnap2 would be associated with profoundly different effects on body weight in a segregating cross and would therefore appear to have no consistent effect. Mol Metab 3 : — Many of these pioneering studies in model organisms also showed that variants in several genes could act together in a nonadditive manner to yield dramatic phenotypic differences MacPhee et al.
Pharmacogenet Genomics 18 : — If you are not found to be a carrier you cannot pass a faulty gene on. The effect sizes of these associations are significant but small—as indicated in the introduction, association studies of complex traits and common disorders rarely find large effect sizes.