Ultrastruct Pathol. B Venous invasion in the parametrial tissue. Optimal management of cervical cancer patients requires accurate assessment of the quality and the quantity of the neoplasm.
Chromosomal abnormalities have been recently detected among granulosa cell tumors and they include trisomy 12, monosomy 22 and chromosome 6 deletion. B The base of tumor has smooth borders without infiltrative pattern. Of these, 15 required conization for diagnosis.
After hysterectomy, no tumor recurrence was noted in 10 women observed for 2 to 14 years. Only 1 case is known to have died of disease with metastasis in the lung. In contrast, adenocarcinoma in situ retains smooth borders left one third. Differential diagnosis. The histologic type of these tumors is heterogeneous, including adenocarcinoma in situ with early stromal invasion, well-differentiated adenocarcinoma, and papillary villoglandular adenocarcinoma.
It arises from ovarian stromal cells It has a poor prognosis It is typically bilateral Treatment involves local excision with adjuvant chemotherapy Tumor cells are strongly positive for cytokeratin. The cytoplasm is moderate in amount, eosinophilic to amphophilic, some having individual cell keratinization with distinct cell borders Fig.
Thus most authors have agreed that for surgically treated stage IB and II cervical carcinomas, the depth of stromal invasion, tumor dimension, the presence or absence of lymphatic vascular space invasion, and pelvic lymph node status are important prognosticators. Measured invasion of stroma no greater than 3 mm in depth and no wider than 7 mm.
The diagnosis is justified only if the endometrium is normal after careful sampling for histologic examination.